4IXE

pcDHFR-NADPH-270

Summary for 4IXE

Entry DOI	10.2210/pdb4ixe/pdb
Related	2CD4 4IXF 4IXG
Descriptor	Dihydrofolate reductase, N~6~-methyl-N~6~-(3,4,5-trifluorophenyl)pyrido[2,3-d]pyrimidine-2,4,6-triamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
Functional Keywords	dihydrofolate reductase inhibitor cofactor ternary complex, reductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological source	Pneumocystis carinii
Total number of polymer chains	1
Total formula weight	24984.23
Authors	Cody, V. (deposition date: 2013-01-25, release date: 2013-05-29, Last modification date: 2023-09-20)
Primary citation	Gangjee, A.,Namjoshi, O.A.,Raghavan, S.,Queener, S.F.,Kisliuk, R.L.,Cody, V. Design, Synthesis, and Molecular Modeling of Novel Pyrido[2,3-d]pyrimidine Analogues As Antifolates; Application of Buchwald-Hartwig Aminations of Heterocycles. J.Med.Chem., 56:4422-4441, 2013 Cited by PubMed: 23627352 DOI: 10.1021/jm400086g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.54 Å)

Structure validation