4QJZ

Pneumocystis carinii dihydrofolate reductase ternary complex with NADPH and the inhibitor 24, (N~6~-METHYL-N~6~-(NAPHTHALEN-1-YL)PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE)

Summary for 4QJZ

Entry DOI	10.2210/pdb4qjz/pdb
Related	4IXE 4QJC
Descriptor	Dihydrofolate reductase, N~6~-methyl-N~6~-(naphthalen-1-yl)pyrido[2,3-d]pyrimidine-2,4,6-triamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
Functional Keywords	rossman fold, hydrolase, nadph and folate inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Pneumocystis carinii
Total number of polymer chains	1
Total formula weight	24980.32
Authors	Cody, V. (deposition date: 2014-06-05, release date: 2015-06-10, Last modification date: 2023-09-20)
Primary citation	Cody, V.,Pace, J.,Namjoshi, O.A.,Gangjee, A. Structure-activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase. Acta Crystallogr F Struct Biol Commun, 71:799-803, 2015 Cited by PubMed: 26057816 DOI: 10.1107/S2053230X15008468 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.61 Å)

Structure validation