Functional Information from GO Data
Chain | GOid | namespace | contents |
D | 0004146 | molecular_function | dihydrofolate reductase activity |
D | 0005739 | cellular_component | mitochondrion |
D | 0006730 | biological_process | one-carbon metabolic process |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0046452 | biological_process | dihydrofolate metabolic process |
D | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
D | 0046655 | biological_process | folic acid metabolic process |
D | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 33M D 301 |
Chain | Residue |
D | ILE10 |
D | TYR129 |
D | THR144 |
D | NDP302 |
D | HOH405 |
D | VAL11 |
D | ALA12 |
D | LEU25 |
D | GLU32 |
D | ILE33 |
D | PHE36 |
D | THR61 |
D | ILE123 |
site_id | AC2 |
Number of Residues | 28 |
Details | BINDING SITE FOR RESIDUE NDP D 302 |
Chain | Residue |
D | VAL11 |
D | ALA12 |
D | ILE19 |
D | GLY20 |
D | ARG21 |
D | SER24 |
D | LEU25 |
D | TRP27 |
D | GLY58 |
D | ARG59 |
D | LYS60 |
D | THR61 |
D | ILE80 |
D | THR81 |
D | ARG82 |
D | LYS96 |
D | ILE123 |
D | GLY124 |
D | GLY125 |
D | ALA126 |
D | GLN127 |
D | LEU128 |
D | TYR129 |
D | ALA131 |
D | 33M301 |
D | HOH412 |
D | HOH453 |
D | HOH473 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GIGrsnsLPWklkk.EisyFkrvT |
Chain | Residue | Details |
D | GLY18-THR40 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
D | ALA12 | |
D | GLY18 | |
D | ARG59 | |
D | THR81 | |
D | GLY124 | |
Chain | Residue | Details |
D | GLU32 | |
D | ARG75 | |