4QJC

Human dihydrofolate reductase ternary complex with NADPH and inhibitor 26 (N~6~-METHYL-N~6~-(3,4,5-TRIFLUOROPHENYL)PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE)

Summary for 4QJC

Entry DOI	10.2210/pdb4qjc/pdb
Related	4IXE 4QJZ
Descriptor	Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N~6~-methyl-N~6~-(3,4,5-trifluorophenyl)pyrido[2,3-d]pyrimidine-2,4,6-triamine, ... (4 entities in total)
Functional Keywords	dihydrofolate reductase, inhibitor binding, rossman fold, hydrolase, cofactor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion : P00374
Total number of polymer chains	1
Total formula weight	22415.22
Authors	Cody, V. (deposition date: 2014-06-03, release date: 2015-06-10, Last modification date: 2023-09-20)
Primary citation	Cody, V.,Pace, J.,Namjoshi, O.A.,Gangjee, A. Structure-activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase. Acta Crystallogr F Struct Biol Commun, 71:799-803, 2015 Cited by PubMed: 26057816 DOI: 10.1107/S2053230X15008468 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.62 Å)

Structure validation