4QJZ

Pneumocystis carinii dihydrofolate reductase ternary complex with NADPH and the inhibitor 24, (N~6~-METHYL-N~6~-(NAPHTHALEN-1-YL)PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE)

4QJZ の概要

• エントリーDOI: 10.2210/pdb4qjz/pdb
• 関連するPDBエントリー: 4IXE 4QJC
• 分子名称: Dihydrofolate reductase, N~6~-methyl-N~6~-(naphthalen-1-yl)pyrido[2,3-d]pyrimidine-2,4,6-triamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• 機能のキーワード: rossman fold, hydrolase, nadph and folate inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Pneumocystis carinii
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24980.32

構造登録者

Cody, V. (登録日: 2014-06-05, 公開日: 2015-06-10, 最終更新日: 2023-09-20)

• 主引用文献: Cody, V.,Pace, J.,Namjoshi, O.A.,Gangjee, A.; Structure-activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase.; Acta Crystallogr F Struct Biol Commun, 71:799-803, 2015; PubMed: 26057816; DOI: 10.1107/S2053230X15008468

実験手法

X-RAY DIFFRACTION (1.61 Å)