4QIK

Crystal structure of the ROQ domain of human Roquin in complex with the TNF23 RNA duplex

Summary for 4QIK

• Entry DOI: 10.2210/pdb4qik/pdb
• Related: 4QIL
• Descriptor: Roquin-1, 5'-R(*AP*C*AP*UP*GP*UP*UP*UP*UP*CP*UP*GP*UP*GP*AP*AP*AP*AP*CP*GP*GP*AP*G)-3', CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: rna duplex, winged-helix motif, mrna secondary structure, mrna decay, immune responses, autoimmunity, rna binding protein-rna complex, rna binding protein/rna
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, P-body (By similarity): Q5TC82
• Total number of polymer chains: 4
• Total formula weight: 90452.68

Authors

Tan, D.,Tong, L. (deposition date: 2014-05-31, release date: 2014-07-16, Last modification date: 2014-08-20)

• Primary citation: Tan, D.,Zhou, M.,Kiledjian, M.,Tong, L.; The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA.; Nat.Struct.Mol.Biol., 21:679-685, 2014; PubMed: 25026078; DOI: 10.1038/nsmb.2857

Experimental method

X-RAY DIFFRACTION (1.9 Å)