4QIK

Crystal structure of the ROQ domain of human Roquin in complex with the TNF23 RNA duplex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003730	molecular_function	mRNA 3'-UTR binding
A	0010608	biological_process	post-transcriptional regulation of gene expression
A	0042129	biological_process	regulation of T cell proliferation
A	0050863	biological_process	regulation of T cell activation
B	0003730	molecular_function	mRNA 3'-UTR binding
B	0010608	biological_process	post-transcriptional regulation of gene expression
B	0042129	biological_process	regulation of T cell proliferation
B	0050863	biological_process	regulation of T cell activation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 501

Chain	Residue
A	TRP184
A	ARG188
A	PHE194
A	HOH773

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 502

Chain	Residue
A	GLY196
A	PRO197
A	ALA198
A	MSE199
A	HOH742

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 503

Chain	Residue
A	GLN144
A	GLY150
A	ARG153
A	HOH911

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 504

Chain	Residue
A	TYR96
A	LYS100
A	LEU145
B	THR93

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site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 505

Chain	Residue
A	SER305
A	ASP310
A	GLN311

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site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 506

Chain	Residue
A	ASN175
A	HOH659
A	HOH918

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site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 507

Chain	Residue
A	SER312
A	LYS314
A	SER315

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site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 508

Chain	Residue
A	ALA186
A	ARG190
A	HOH676
A	HOH770
B	HOH681

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site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 501

Chain	Residue
B	ARG188
B	PHE194

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site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL B 502

Chain	Residue
A	GLU148
A	ARG151
A	HOH855
B	GLU147
B	GLU148
B	ARG151

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 503

Chain	Residue
B	GLN144
B	GLY150
B	ARG153
B	HOH911

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 504

Chain	Residue
B	LYS256
B	LYS270
B	GLU271

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 505

Chain	Residue
A	HOH697
B	ALA186
B	ARG190
B	HOH682

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 506

Chain	Residue
B	ARG233
B	PHE234
B	HOH963

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site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 507

Chain	Residue
B	MSE155
B	ARG156
B	ILE363
B	ASP364
B	GLN376
B	HOH725
B	HOH881

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