4QIK

Crystal structure of the ROQ domain of human Roquin in complex with the TNF23 RNA duplex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Roquin-1	polymer	330	37542.7	2	UniProt (Q5TC82) Pfam (PF21206) Pfam (PF18386)	Homo sapiens (human)	Roquin, RING finger and C3H zinc finger protein 1, RING finger and CCCH-type zinc finger domain-containing protein 1, RING finger protein 198
2	C, D (C, D)	5'-R(*AP*C*AP*UP*GP*UP*UP*UP*UP*CP*UP*GP*UP*GP*AP*AP*AP*AP*CP*GP*GP*AP*G)-3'	polymer	23	7389.4	2
3	E, F, G, H, I... (A, B)	CHLORIDE ION	non-polymer		35.5	14	Chemie (CL)
4	S (B)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5	T, U, V, W (A, B, C, D)	water	water		18.0	885	Chemie (HOH)

Sequence modifications

A, B: 88 - 407 (UniProt: Q5TC82)

PDB	External Database	Details
Mse 86	-	expression tag
Ala 87	-	expression tag
Leu 408	-	expression tag
Glu 409	-	expression tag
His 410	-	expression tag
His 411	-	expression tag
His 412	-	expression tag
His 413	-	expression tag
His 414	-	expression tag
His 415	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	89864.2
Non-Polymers*	Number of molecules	15
	Total formula weight	588.4
All*	Total formula weight	90452.7

*Water molecules are not included.