4Q5V

Crystal structure of the catalytic core of human DNA polymerase alpha in ternary complex with an RNA-primed DNA template and aphidicolin

Summary for 4Q5V

Entry DOI	10.2210/pdb4q5v/pdb
Descriptor	DNA polymerase alpha catalytic subunit, RNA primer, DNA template, ... (5 entities in total)
Functional Keywords	b-family dna polymerase, dna replication, transferase-dna-rna complex, transferase/dna/rna
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P09884
Total number of polymer chains	6
Total formula weight	231733.23
Authors	Baranovskiy, A.G.,Babayeva, N.D.,Suwa, Y.,Gu, J.,Tahirov, T.H. (deposition date: 2014-04-17, release date: 2014-11-26, Last modification date: 2024-02-28)
Primary citation	Baranovskiy, A.G.,Babayeva, N.D.,Suwa, Y.,Gu, J.,Pavlov, Y.I.,Tahirov, T.H. Structural basis for inhibition of DNA replication by aphidicolin. Nucleic Acids Res., 42:14013-14021, 2014 Cited by PubMed: 25429975 DOI: 10.1093/nar/gku1209 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.52 Å)

Structure validation