4Q5V
Crystal structure of the catalytic core of human DNA polymerase alpha in ternary complex with an RNA-primed DNA template and aphidicolin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E | DNA polymerase alpha catalytic subunit | polymer | 922 | 105583.8 | 2 | UniProt (P09884) Pfam (PF03104) Pfam (PF00136) In PDB | Homo sapiens (human) | DNA polymerase alpha catalytic subunit p180 |
| 2 | B, F | RNA primer | polymer | 11 | 3521.2 | 2 | |||
| 3 | C, G | DNA template | polymer | 21 | 6423.2 | 2 | |||
| 4 | A, E | (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-4,9-bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocyclohepta[a]naphthale ne-3,9-diol | non-polymer | 338.5 | 2 | Chemie (2ZE) | |||
| 5 | water | water | 18.0 | 151 | Chemie (HOH) |
Sequence modifications
A, E: 336 - 1257 (UniProt: P09884)
| PDB | External Database | Details |
|---|---|---|
| Ala 516 | Val 516 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 231056.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 677.0 | |
| All* | Total formula weight | 231733.2 |
