4Q5V
Crystal structure of the catalytic core of human DNA polymerase alpha in ternary complex with an RNA-primed DNA template and aphidicolin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, E) | DNA polymerase alpha catalytic subunit | polymer | 922 | 105583.8 | 2 | UniProt (P09884) Pfam (PF03104) Pfam (PF00136) | Homo sapiens (human) | DNA polymerase alpha catalytic subunit p180 |
| 2 | B, E (B, F) | RNA primer | polymer | 11 | 3521.2 | 2 | |||
| 3 | C, F (C, G) | DNA template | polymer | 21 | 6423.2 | 2 | |||
| 4 | G, H (A, E) | (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-4,9-bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocyclohepta[a]naphthale ne-3,9-diol | non-polymer | 338.5 | 2 | Chemie (2ZE) PubChem (2210) PubChem (21670948) PubChem (24867289) PubChem (38194) PubChem (51340276) PubChem (336497) PubChem (440910) PubChem (71242650) PubChem (71774398) PubChem (457964) PubChem (463725) PubChem (73345172) PubChem (98064545) PubChem (117987430) PubChem (92846408) PubChem (10947751) PubChem (98064543) PubChem (98064544) PubChem (7048536) PubChem (131668610) PubChem (146158800) PubChem (163045155) PubChem (163045156) PubChem (163045157) PubChem (163045158) PubChem (164667958) | |||
| 5 | I, J, K, L, M... (A, B, C, E, F...) | water | water | 18.0 | 151 | Chemie (HOH) |
Sequence modifications
A, E: 336 - 1257 (UniProt: P09884)
| PDB | External Database | Details |
|---|---|---|
| Ala 516 | Val 516 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 231056.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 677.0 | |
| All* | Total formula weight | 231733.2 |
