4Q5V

Crystal structure of the catalytic core of human DNA polymerase alpha in ternary complex with an RNA-primed DNA template and aphidicolin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	1902975	biological_process	mitotic DNA replication initiation
E	0000166	molecular_function	nucleotide binding
E	0003676	molecular_function	nucleic acid binding
E	0003677	molecular_function	DNA binding
E	0003887	molecular_function	DNA-directed DNA polymerase activity
E	1902975	biological_process	mitotic DNA replication initiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 2ZE A 1301

Chain	Residue
A	LEU864
C	DG111
A	TYR865
A	ASN954
A	SER955
A	GLY958
A	ASP1004
A	HOH1411
A	HOH1429
B	DC11

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site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 2ZE E 1301

Chain	Residue
E	LEU864
E	TYR865
E	ASN954
E	SER955
E	GLY958
E	ASP1004
E	HOH1421
E	HOH1423
F	DC211
G	DG311

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Functional Information from PROSITE/UniProt

site_id	PS00116
Number of Residues	9
Details	DNA_POLYMERASE_B DNA polymerase family B signature. YGDTDSIMI

Chain	Residue	Details
A	TYR1000-ILE1008

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR406
E	THR406

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P33609

Chain	Residue	Details
A	LYS970
E	LYS970

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