4Q2G

CRYSTAL STRUCTURE OF AN INTRAMEMBRANE CDP-DAG SYNTHETASE CENTRAL FOR PHOSPHOLIPID BIOSYNTHESIS (S200C/S223C, inactive mutant)

Summary for 4Q2G

• Entry DOI: 10.2210/pdb4q2g/pdb
• Related: 4Q2E
• Descriptor: Phosphatidate cytidylyltransferase, MERCURY (II) ION, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: intramembrane enzyme, cdsa fold, phospholipid biosynthesis lipid metabolism, ctp and phosphatidic acid binding, nucleotidyltransferase, membrane, transferase
• Biological source: Thermotoga maritima MSB8
• Cellular location: Cell membrane; Multi-pass membrane protein (By similarity): Q9X1B7
• Total number of polymer chains: 2
• Total formula weight: 66117.56

Authors

Liu, X.,Yin, Y.,Wu, J.,Liu, Z. (deposition date: 2014-04-08, release date: 2014-07-02, Last modification date: 2024-03-20)

• Primary citation: Liu, X.,Yin, Y.,Wu, J.,Liu, Z.; Structure and mechanism of an intramembrane liponucleotide synthetase central for phospholipid biosynthesis; Nat Commun, 5:4244-4244, 2014; PubMed: 24968740; DOI: 10.1038/ncomms5244

Experimental method

X-RAY DIFFRACTION (3.4 Å)