4Q2G

CRYSTAL STRUCTURE OF AN INTRAMEMBRANE CDP-DAG SYNTHETASE CENTRAL FOR PHOSPHOLIPID BIOSYNTHESIS (S200C/S223C, inactive mutant)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004605	molecular_function	phosphatidate cytidylyltransferase activity
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0008654	biological_process	phospholipid biosynthetic process
A	0016020	cellular_component	membrane
A	0016024	biological_process	CDP-diacylglycerol biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
A	0016779	molecular_function	nucleotidyltransferase activity
B	0004605	molecular_function	phosphatidate cytidylyltransferase activity
B	0005886	cellular_component	plasma membrane
B	0006629	biological_process	lipid metabolic process
B	0008654	biological_process	phospholipid biosynthetic process
B	0016020	cellular_component	membrane
B	0016024	biological_process	CDP-diacylglycerol biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
B	0016779	molecular_function	nucleotidyltransferase activity

Functional Information from PROSITE/UniProt

site_id	PS01315
Number of Residues	27
Details	CDS Phosphatidate cytidylyltransferase signature. SaLKRhygvKDsGktLPgHGGMlDRID

Chain	Residue	Details
A	SER243-ASP269

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	320
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	PHE37-ILE57
B	PHE75-PRO95
B	ILE101-PHE121
B	VAL124-ILE144
B	GLY149-PHE169
B	GLU190-VAL210
B	LEU213-ILE233
B	ILE268-VAL288
A	PHE75-PRO95
A	ILE101-PHE121
A	VAL124-ILE144
A	GLY149-PHE169
A	GLU190-VAL210
A	LEU213-ILE233
A	ILE268-VAL288
B	PHE37-ILE57

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