4Q0A
Vitamin D Receptor complex with lithocholic acid
Summary for 4Q0A
Entry DOI | 10.2210/pdb4q0a/pdb |
Related | 2HC4 2HCD |
Descriptor | Vitamin D3 receptor A, Nuclear receptor coactivator 2, (3beta,5beta,14beta,17alpha)-3-hydroxycholan-24-oic acid, ... (4 entities in total) |
Functional Keywords | alpha-helical sandwich, transcription factor, calcitriol binding, dna binding, nucleus, gene regulation |
Biological source | Danio rerio (leopard danio,zebra danio,zebra fish) More |
Cellular location | Nucleus: Q9PTN2 Q15596 |
Total number of polymer chains | 2 |
Total formula weight | 36032.31 |
Authors | Belorusova, A.,Rochel, N. (deposition date: 2014-04-01, release date: 2014-07-02, Last modification date: 2024-02-28) |
Primary citation | Belorusova, A.Y.,Eberhardt, J.,Potier, N.,Stote, R.H.,Dejaegere, A.,Rochel, N. Structural insights into the molecular mechanism of vitamin d receptor activation by lithocholic Acid involving a new mode of ligand recognition. J.Med.Chem., 57:4710-4719, 2014 Cited by PubMed: 24818857DOI: 10.1021/jm5002524 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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