4PXU

Structural basis for the assembly of the mitotic motor kinesin-5 into bipolar tetramers

Summary for 4PXU

Related4PXT
DescriptorBipolar kinesin KRP-130, (4S)-2-METHYL-2,4-PENTANEDIOL (3 entities in total)
Functional Keywordscoiled-coil, bipolar assembly domain of kinesin-5, bipolar tetramers, anti-parallel four-helix bundle, kinesin-5 functions via a "sliding filament" mechanism, crosslinking adjacent microtubules into bundles throughout the mitotic spindle, microtubules, cell cycle
Biological sourceDrosophila melanogaster (Fruit fly)
Total number of polymer chains2
Total molecular weight48584.97
Authors
Scholey, J.E.,Nithianantham, S.,Scholey, J.M.,Al-Bassam, J. (deposition date: 2014-03-25, release date: 2014-04-23)
Primary citation
Scholey, J.E.,Nithianantham, S.,Scholey, J.M.,Al-Bassam, J.
Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers.
Elife, 3:e02217-e02217, 2014
PubMed: 24714498 (PDB entries with the same primary citation)
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.601 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.253500.8%5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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