4PQU
Crystal structure of HIV-1 Reverse Transcriptase in complex with RNA/DNA and dATP
Summary for 4PQU
Entry DOI | 10.2210/pdb4pqu/pdb |
Related | 1HYS 3V4I 3V6D 3V81 4PUO 4PWD 4Q0B |
Descriptor | HIV-1 Reverse Transcriptase, p66 subunit, HIV-1 Reverse Transcriptase, p51 subunit, 5'-R(*AP*UP*GP*GP*UP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*UP*GP*UP*G)-3', ... (10 entities in total) |
Functional Keywords | fingers, palm, thumb, connection, rnase h, nucleotidyltransferase, dna-directed dna polymerase, rna-directed dna polymerase, transferase, hydrolase-dna-rna complex, hydrolase/dna/rna |
Biological source | Human immunodeficiency virus type 1 (HIV-1) More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366 |
Total number of polymer chains | 8 |
Total formula weight | 260476.84 |
Authors | Das, K.,Bandwar, R.P.,Arnold, E. (deposition date: 2014-03-04, release date: 2014-06-18, Last modification date: 2023-09-20) |
Primary citation | Das, K.,Martinez, S.E.,Bandwar, R.P.,Arnold, E. Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage. Nucleic Acids Res., 42:8125-8137, 2014 Cited by PubMed: 24880687DOI: 10.1093/nar/gku487 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.508 Å) |
Structure validation
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