4PQU
Crystal structure of HIV-1 Reverse Transcriptase in complex with RNA/DNA and dATP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| A | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| A | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| B | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| B | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| C | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| C | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| D | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| D | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE DTP A 601 |
| Chain | Residue |
| A | LYS65 |
| A | GLN151 |
| A | ASP185 |
| A | LYS219 |
| A | MG602 |
| A | MG603 |
| A | HOH779 |
| P | DG822 |
| T | U705 |
| T | C706 |
| A | ARG72 |
| A | LEU74 |
| A | ASP110 |
| A | VAL111 |
| A | GLY112 |
| A | ASP113 |
| A | ALA114 |
| A | TYR115 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 602 |
| Chain | Residue |
| A | ASP110 |
| A | VAL111 |
| A | ASP185 |
| A | DTP601 |
| A | MG603 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A 603 |
| Chain | Residue |
| A | ASP110 |
| A | ASP185 |
| A | ASP186 |
| A | DTP601 |
| A | MG602 |
| A | HOH779 |
| P | DG822 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 604 |
| Chain | Residue |
| A | ALA408 |
| A | THR409 |
| A | HOH797 |
| A | HOH802 |
| B | GLN394 |
| B | THR397 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 605 |
| Chain | Residue |
| A | LYS101 |
| A | LYS102 |
| A | LYS103 |
| A | VAL106 |
| A | TYR188 |
| A | PRO236 |
| A | TYR318 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 606 |
| Chain | Residue |
| A | LYS331 |
| A | GLY333 |
| A | GLN334 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 607 |
| Chain | Residue |
| A | TYR427 |
| A | GLN428 |
| A | LYS528 |
| A | GLU529 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 501 |
| Chain | Residue |
| B | TRP24 |
| B | GLU399 |
| B | TRP402 |
| B | HOH716 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 502 |
| Chain | Residue |
| A | ILE380 |
| B | PRO25 |
| B | THR400 |
| B | GLU404 |
| B | HOH681 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 503 |
| Chain | Residue |
| B | TRP266 |
| B | PRO420 |
| B | PRO421 |
| B | LEU422 |
| B | VAL423 |
| site_id | BC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE DTP C 601 |
| Chain | Residue |
| C | LYS65 |
| C | ARG72 |
| C | LEU74 |
| C | ASP110 |
| C | VAL111 |
| C | GLY112 |
| C | ASP113 |
| C | ALA114 |
| C | TYR115 |
| C | GLN151 |
| C | ASP185 |
| C | LYS219 |
| C | MG602 |
| C | MG603 |
| C | HOH776 |
| E | U705 |
| E | C706 |
| F | DG822 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 602 |
| Chain | Residue |
| C | ASP110 |
| C | VAL111 |
| C | ASP185 |
| C | DTP601 |
| C | MG603 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG C 603 |
| Chain | Residue |
| C | ASP110 |
| C | ASP185 |
| C | ASP186 |
| C | DTP601 |
| C | MG602 |
| C | HOH776 |
| F | DG822 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 604 |
| Chain | Residue |
| C | THR403 |
| C | GLU404 |
| C | TYR405 |
| D | LYS331 |
| D | GLN332 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 501 |
| Chain | Residue |
| A | LYS311 |
| D | ARG277 |
| D | GLN278 |
| D | LYS281 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 502 |
| Chain | Residue |
| D | TRP266 |
| D | PRO420 |
| D | PRO421 |
| D | LEU422 |
| D | VAL423 |
| D | HOH639 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 380 |
| Details | Domain: {"description":"Reverse transcriptase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00405","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Region: {"description":"RT 'primer grip'"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 64 |
| Details | Motif: {"description":"Tryptophan repeat motif"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Site: {"description":"Essential for RT p66/p51 heterodimerization"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Site: {"description":"Cleavage; by viral protease; partial"} |
| Chain | Residue | Details |
