4PQU
Crystal structure of HIV-1 Reverse Transcriptase in complex with RNA/DNA and dATP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | HIV-1 Reverse Transcriptase, p66 subunit | polymer | 556 | 64022.4 | 2 | UniProt (P03366) | Human immunodeficiency virus type 1 (HIV-1) | Reverse transcriptase/ribonuclease H, Exoribonuclease H, p66 RT |
| 2 | B, D (B, D) | HIV-1 Reverse Transcriptase, p51 subunit | polymer | 428 | 50039.5 | 2 | UniProt (P03366) | Human immunodeficiency virus type 1 (HIV-1) | p51 RT |
| 3 | E, G (T, E) | 5'-R(*AP*UP*GP*GP*UP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*UP*GP*UP*G)-3' | polymer | 27 | 8759.3 | 2 | |||
| 4 | F, H (P, F) | 5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*CP*G)-3' | polymer | 21 | 6416.1 | 2 | |||
| 5 | I, S (A, C) | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE | non-polymer | 491.2 | 2 | Chemie (DTP) PubChem (622) PubChem (15993) PubChem (44119995) PubChem (448808) PubChem (46936612) PubChem (57233913) PubChem (91632917) PubChem (92341128) PubChem (92449119) PubChem (92449120) PubChem (89346292) PubChem (129069956) PubChem (171699368) | |||
| 6 | J, K, T, U (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) PubChem (888) | |||
| 7 | L (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 8 | M, N, O, P, R... (A, B, C, D) | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
| 9 | Q (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 10 | AA, BA, CA, DA, EA... (C, D, T, P, E...) | water | water | 18.0 | 435 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 554 (UniProt: P03366)
B, D: 1 - 428 (UniProt: P03366)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | expression tag |
| Val 0 | - | expression tag |
| Cys 258 | Gln 857 | engineered mutation |
| Ser 280 | Cys 879 | engineered mutation |
| Asn 498 | Asp 1097 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 280 | Cys 879 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 258474.6 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2002.3 | |
| All* | Total formula weight | 260476.8 |
