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3V81

Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and the nonnucleoside inhibitor nevirapine

Summary for 3V81
Entry DOI10.2210/pdb3v81/pdb
Related1RTD 1VRT 2ZD1 3JSM 3KLE 3KLF 3V4I 3V6D
DescriptorHIV-1 Reverse Transcriptase P66 subunit, HIV-1 Reverse Transcriptase P51 subunit, DNA (5'-D(*AP*TP*GP*GP*AP*AP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3'), ... (5 entities in total)
Functional Keywordsp51/p66, hetero dimer, nnrti, nonnucleoside inhibitor, aids, dna, recombination, rna-directed dna polymerase, viramune, dna polymerase, endonuclease, hydrolase, multifunctional enzyme, transferase, transferase-dna complex, azt, zidovudine, transferase/dna
Biological sourceHuman immunodeficiency virus type 1 BH10 (HIV-1)
More
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
Total number of polymer chains8
Total formula weight258469.78
Authors
Das, K.,Martinez, S.E.,Arnold, E. (deposition date: 2011-12-22, release date: 2012-01-18, Last modification date: 2023-09-13)
Primary citationDas, K.,Martinez, S.E.,Bauman, J.D.,Arnold, E.
HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism.
Nat.Struct.Mol.Biol., 19:253-259, 2012
Cited by
PubMed: 22266819
DOI: 10.1038/nsmb.2223
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8503 Å)
Structure validation

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