3KLE
Crystal structure of AZT-resistant HIV-1 Reverse Transcriptase crosslinked to a DSDNA with a bound excision product, AZTPPPPA
Summary for 3KLE
Entry DOI | 10.2210/pdb3kle/pdb |
Related | 3KLF 3KLG 3KLH 3KLI |
Related PRD ID | PRD_900032 |
Descriptor | Reverse transcriptase/ribonuclease H, p51 RT, DNA (25-MER), ... (9 entities in total) |
Functional Keywords | azt resistance mechanism, hiv-1, reverse transcriptase, rt, azt, resistance mutations, p51/p66, nucleoside inhibitor, nucleotide excision, thymidine analog mutations, aids, hiv, dna polymerase, nrti, nrti resistance, aztppppa, aztp4a, azt adenosine dinucleoside tetraphosphate, dna-directed dna polymerase, endonuclease, hydrolase, magnesium, metal-binding, multifunctional enzyme, myristate, nuclease, rna-directed dna polymerase, transferase, transferase-dna complex, transferase/dna |
Biological source | Human immunodeficiency virus type 1 (HIV-1) More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366 |
Total number of polymer chains | 16 |
Total formula weight | 526900.62 |
Authors | Tu, X.,Das, K.,Sarafianos, S.G.,Arnold, E. (deposition date: 2009-11-07, release date: 2010-09-22, Last modification date: 2021-10-13) |
Primary citation | Tu, X.,Das, K.,Han, Q.,Bauman, J.D.,Clark, A.D.,Hou, X.,Frenkel, Y.V.,Gaffney, B.L.,Jones, R.A.,Boyer, P.L.,Hughes, S.H.,Sarafianos, S.G.,Arnold, E. Structural basis of HIV-1 resistance to AZT by excision. Nat.Struct.Mol.Biol., 17:1202-1209, 2010 Cited by PubMed: 20852643DOI: 10.1038/nsmb.1908 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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