3KLE

Crystal structure of AZT-resistant HIV-1 Reverse Transcriptase crosslinked to a DSDNA with a bound excision product, AZTPPPPA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003964	molecular_function	RNA-directed DNA polymerase activity
A	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
A	0006278	biological_process	RNA-templated DNA biosynthetic process
B	0003964	molecular_function	RNA-directed DNA polymerase activity
B	0006278	biological_process	RNA-templated DNA biosynthetic process
E	0003676	molecular_function	nucleic acid binding
E	0003964	molecular_function	RNA-directed DNA polymerase activity
E	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
E	0006278	biological_process	RNA-templated DNA biosynthetic process
F	0003964	molecular_function	RNA-directed DNA polymerase activity
F	0006278	biological_process	RNA-templated DNA biosynthetic process
I	0003676	molecular_function	nucleic acid binding
I	0003964	molecular_function	RNA-directed DNA polymerase activity
I	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
I	0006278	biological_process	RNA-templated DNA biosynthetic process
J	0003964	molecular_function	RNA-directed DNA polymerase activity
J	0006278	biological_process	RNA-templated DNA biosynthetic process
M	0003676	molecular_function	nucleic acid binding
M	0003964	molecular_function	RNA-directed DNA polymerase activity
M	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
M	0006278	biological_process	RNA-templated DNA biosynthetic process
N	0003964	molecular_function	RNA-directed DNA polymerase activity
N	0006278	biological_process	RNA-templated DNA biosynthetic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	760
Details	Domain: {"description":"Reverse transcriptase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00405","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	492
Details	Domain: {"description":"RNase H type-1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00408","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	32
Details	Region: {"description":"RT 'primer grip'"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	128
Details	Motif: {"description":"Tryptophan repeat motif"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	16
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	16
Details	Site: {"description":"Essential for RT p66/p51 heterodimerization"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Site: {"description":"Cleavage; by viral protease; partial"}

Chain

Residue

Details

---