4PNI

Bovine G protein-coupled receptor kinase 1 in complex with GSK2163632A

4PNI の概要

• エントリーDOI: 10.2210/pdb4pni/pdb
• 関連するPDBエントリー: 4L9I 4PNK
• 分子名称: Rhodopsin kinase, 3-[(2-{[1-(N,N-dimethylglycyl)-6-methoxy-4,4-dimethyl-1,2,3,4-tetrahydroquinolin-7-yl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]thiophene-2-carboxamide, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: agc family kinase, ser/thr kinase, rgs homology domain, g protein coupled receptor kinase, grk, grk1, rhodopsin kinase, hydrolyase, gpcr, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Bos taurus (Bovine)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 63773.20

構造登録者

Homan, K.T.,Tesmer, J.J.G. (登録日: 2014-05-23, 公開日: 2014-10-08, 最終更新日: 2023-12-27)

• 主引用文献: Homan, K.T.,Larimore, K.M.,Elkins, J.M.,Szklarz, M.,Knapp, S.,Tesmer, J.J.; Identification and structure-function analysis of subfamily selective g protein-coupled receptor kinase inhibitors.; Acs Chem.Biol., 10:310-319, 2015; PubMed: 25238254; DOI: 10.1021/cb5006323

実験手法

X-RAY DIFFRACTION (1.85 Å)