4P5E

CRYSTAL STRUCTURE OF HUMAN DNPH1 (RCL) WITH 6-NAPHTHYL-PURINE-RIBOSIDE-MONOPHOSPHATE

Summary for 4P5E

• Entry DOI: 10.2210/pdb4p5e/pdb
• Related: 4FYI 4P5D
• Descriptor: 2'-deoxynucleoside 5'-phosphate N-hydrolase 1, 6-(naphthalen-2-yl)-9-(5-O-phosphono-beta-D-ribofuranosyl)-9H-purine, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: rcl, dnph1, inhibitor, rossmann fold, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: O43598
• Total number of polymer chains: 2
• Total formula weight: 35373.44

Authors

Padilla, A.,Labesse, G.,Kaminski, P.A. (deposition date: 2014-03-16, release date: 2014-08-20, Last modification date: 2023-12-20)

• Primary citation: Amiable, C.,Paoletti, J.,Haouz, A.,Padilla, A.,Labesse, G.,Kaminski, P.A.,Pochet, S.; 6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: Synthesis, structural studies and cytotoxic activities.; Eur.J.Med.Chem., 85C:418-437, 2014; PubMed: 25108359; DOI: 10.1016/j.ejmech.2014.07.110

Experimental method

X-RAY DIFFRACTION (1.35 Å)