4OYT

Crystal structure of ternary complex of Plasmodium vivax SHMT with D-serine and folinic acid

4OYT の概要

• エントリーDOI: 10.2210/pdb4oyt/pdb
• 関連するPDBエントリー: 4O6Z 4PFF 4PFN
• 分子名称: Serine hydroxymethyltransferase, putative, (2R)-2-[(E)-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]-3-oxidanyl-propanoic acid, N-{[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-L-glutamic acid, ... (7 entities in total)
• 機能のキーワード: alpha and beta protein, transferase, methyltransferase activity
• 由来する生物種: Plasmodium vivax
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 150668.92

構造登録者

Chitnumsub, P.,Jaruwat, A.,Leartsakulpanich, U. (登録日: 2014-02-13, 公開日: 2014-12-10, 最終更新日: 2023-09-27)

• 主引用文献: Chitnumsub, P.,Jaruwat, A.,Riangrungroj, P.,Ittarat, W.,Noytanom, K.,Oonanant, W.,Vanichthanankul, J.,Chuankhayan, P.,Maenpuen, S.,Chen, C.J.,Chaiyen, P.,Yuthavong, Y.,Leartsakulpanich, U.; Structures of Plasmodium vivax serine hydroxymethyltransferase: implications for ligand-binding specificity and functional control.; Acta Crystallogr.,Sect.D, 70:3177-3186, 2014; PubMed: 25478836; DOI: 10.1107/S1399004714023128

実験手法

X-RAY DIFFRACTION (2.4 Å)