4OVN
Voltage-gated Sodium Channel 1.5 (Nav1.5) C-terminal domain in complex with Calmodulin poised for activation
Summary for 4OVN
Entry DOI | 10.2210/pdb4ovn/pdb |
Descriptor | Calmodulin, Sodium channel protein type 5 subunit alpha, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | scn5a, voltage gated sodium channel, calmodulin, metal binding protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 10 |
Total formula weight | 180930.14 |
Authors | Gabelli, S.B.,Bianchet, M.A.,Boto, A.,Jakoncic, J.,Tomaselli, G.F.,Amzel, L.M. (deposition date: 2013-12-10, release date: 2014-12-03, Last modification date: 2023-12-27) |
Primary citation | Gabelli, S.B.,Boto, A.,Kuhns, V.H.,Bianchet, M.A.,Farinelli, F.,Aripirala, S.,Yoder, J.,Jakoncic, J.,Tomaselli, G.F.,Amzel, L.M. Regulation of the NaV1.5 cytoplasmic domain by calmodulin. Nat Commun, 5:5126-, 2014 Cited by PubMed: 25370050DOI: 10.1038/ncomms6126 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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