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4OVN

Voltage-gated Sodium Channel 1.5 (Nav1.5) C-terminal domain in complex with Calmodulin poised for activation

Functional Information from GO Data
ChainGOidnamespacecontents
A0000086biological_processG2/M transition of mitotic cell cycle
A0000922cellular_componentspindle pole
A0002027biological_processregulation of heart rate
A0005509molecular_functioncalcium ion binding
A0005513biological_processdetection of calcium ion
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005819cellular_componentspindle
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005876cellular_componentspindle microtubule
A0005886cellular_componentplasma membrane
A0007186biological_processG protein-coupled receptor signaling pathway
A0008076cellular_componentvoltage-gated potassium channel complex
A0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
A0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
A0010856molecular_functionadenylate cyclase activator activity
A0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A0016020cellular_componentmembrane
A0016240biological_processautophagosome membrane docking
A0019855molecular_functioncalcium channel inhibitor activity
A0019901molecular_functionprotein kinase binding
A0021762biological_processsubstantia nigra development
A0030017cellular_componentsarcomere
A0031432molecular_functiontitin binding
A0031514cellular_componentmotile cilium
A0031954biological_processpositive regulation of protein autophosphorylation
A0031982cellular_componentvesicle
A0032465biological_processregulation of cytokinesis
A0032516biological_processobsolete positive regulation of phosphoprotein phosphatase activity
A0032991cellular_componentprotein-containing complex
A0034704cellular_componentcalcium channel complex
A0035307biological_processobsolete positive regulation of protein dephosphorylation
A0035458biological_processcellular response to interferon-beta
A0043209cellular_componentmyelin sheath
A0043539molecular_functionprotein serine/threonine kinase activator activity
A0044305cellular_componentcalyx of Held
A0044325molecular_functiontransmembrane transporter binding
A0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
A0046872molecular_functionmetal ion binding
A0048306molecular_functioncalcium-dependent protein binding
A0050848biological_processregulation of calcium-mediated signaling
A0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
A0051592biological_processresponse to calcium ion
A0055117biological_processregulation of cardiac muscle contraction
A0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
A0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
A0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
A0071346biological_processcellular response to type II interferon
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0072542molecular_functionprotein phosphatase activator activity
A0097225cellular_componentsperm midpiece
A0098901biological_processregulation of cardiac muscle cell action potential
A0099523cellular_componentpresynaptic cytosol
A0140056biological_processorganelle localization by membrane tethering
A0140238biological_processpresynaptic endocytosis
A1901020biological_processnegative regulation of calcium ion transmembrane transporter activity
A1901842biological_processnegative regulation of high voltage-gated calcium channel activity
A1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
A1902494cellular_componentcatalytic complex
A1905913biological_processnegative regulation of calcium ion export across plasma membrane
A1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
B0000086biological_processG2/M transition of mitotic cell cycle
B0000922cellular_componentspindle pole
B0002027biological_processregulation of heart rate
B0005509molecular_functioncalcium ion binding
B0005513biological_processdetection of calcium ion
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005876cellular_componentspindle microtubule
B0005886cellular_componentplasma membrane
B0007186biological_processG protein-coupled receptor signaling pathway
B0008076cellular_componentvoltage-gated potassium channel complex
B0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
B0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
B0010856molecular_functionadenylate cyclase activator activity
B0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B0016020cellular_componentmembrane
B0016240biological_processautophagosome membrane docking
B0019855molecular_functioncalcium channel inhibitor activity
B0019901molecular_functionprotein kinase binding
B0021762biological_processsubstantia nigra development
B0030017cellular_componentsarcomere
B0031432molecular_functiontitin binding
B0031514cellular_componentmotile cilium
B0031954biological_processpositive regulation of protein autophosphorylation
B0031982cellular_componentvesicle
B0032465biological_processregulation of cytokinesis
B0032516biological_processobsolete positive regulation of phosphoprotein phosphatase activity
B0032991cellular_componentprotein-containing complex
B0034704cellular_componentcalcium channel complex
B0035307biological_processobsolete positive regulation of protein dephosphorylation
B0035458biological_processcellular response to interferon-beta
B0043209cellular_componentmyelin sheath
B0043539molecular_functionprotein serine/threonine kinase activator activity
B0044305cellular_componentcalyx of Held
B0044325molecular_functiontransmembrane transporter binding
B0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
B0046872molecular_functionmetal ion binding
B0048306molecular_functioncalcium-dependent protein binding
B0050848biological_processregulation of calcium-mediated signaling
B0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
B0051592biological_processresponse to calcium ion
B0055117biological_processregulation of cardiac muscle contraction
B0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
B0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
B0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
B0071346biological_processcellular response to type II interferon
B0071902biological_processpositive regulation of protein serine/threonine kinase activity
B0072542molecular_functionprotein phosphatase activator activity
B0097225cellular_componentsperm midpiece
B0098901biological_processregulation of cardiac muscle cell action potential
B0099523cellular_componentpresynaptic cytosol
B0140056biological_processorganelle localization by membrane tethering
B0140238biological_processpresynaptic endocytosis
B1901020biological_processnegative regulation of calcium ion transmembrane transporter activity
B1901842biological_processnegative regulation of high voltage-gated calcium channel activity
B1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
B1902494cellular_componentcatalytic complex
B1905913biological_processnegative regulation of calcium ion export across plasma membrane
B1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
C0000086biological_processG2/M transition of mitotic cell cycle
C0000922cellular_componentspindle pole
C0002027biological_processregulation of heart rate
C0005509molecular_functioncalcium ion binding
C0005513biological_processdetection of calcium ion
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005876cellular_componentspindle microtubule
C0005886cellular_componentplasma membrane
C0007186biological_processG protein-coupled receptor signaling pathway
C0008076cellular_componentvoltage-gated potassium channel complex
C0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
C0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
C0010856molecular_functionadenylate cyclase activator activity
C0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C0016020cellular_componentmembrane
C0016240biological_processautophagosome membrane docking
C0019855molecular_functioncalcium channel inhibitor activity
C0019901molecular_functionprotein kinase binding
C0021762biological_processsubstantia nigra development
C0030017cellular_componentsarcomere
C0031432molecular_functiontitin binding
C0031514cellular_componentmotile cilium
C0031954biological_processpositive regulation of protein autophosphorylation
C0031982cellular_componentvesicle
C0032465biological_processregulation of cytokinesis
C0032516biological_processobsolete positive regulation of phosphoprotein phosphatase activity
C0032991cellular_componentprotein-containing complex
C0034704cellular_componentcalcium channel complex
C0035307biological_processobsolete positive regulation of protein dephosphorylation
C0035458biological_processcellular response to interferon-beta
C0043209cellular_componentmyelin sheath
C0043539molecular_functionprotein serine/threonine kinase activator activity
C0044305cellular_componentcalyx of Held
C0044325molecular_functiontransmembrane transporter binding
C0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
C0046872molecular_functionmetal ion binding
C0048306molecular_functioncalcium-dependent protein binding
C0050848biological_processregulation of calcium-mediated signaling
C0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
C0051592biological_processresponse to calcium ion
C0055117biological_processregulation of cardiac muscle contraction
C0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
C0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
C0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
C0071346biological_processcellular response to type II interferon
C0071902biological_processpositive regulation of protein serine/threonine kinase activity
C0072542molecular_functionprotein phosphatase activator activity
C0097225cellular_componentsperm midpiece
C0098901biological_processregulation of cardiac muscle cell action potential
C0099523cellular_componentpresynaptic cytosol
C0140056biological_processorganelle localization by membrane tethering
C0140238biological_processpresynaptic endocytosis
C1901020biological_processnegative regulation of calcium ion transmembrane transporter activity
C1901842biological_processnegative regulation of high voltage-gated calcium channel activity
C1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
C1902494cellular_componentcatalytic complex
C1905913biological_processnegative regulation of calcium ion export across plasma membrane
C1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
D0000086biological_processG2/M transition of mitotic cell cycle
D0000922cellular_componentspindle pole
D0002027biological_processregulation of heart rate
D0005509molecular_functioncalcium ion binding
D0005513biological_processdetection of calcium ion
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005813cellular_componentcentrosome
D0005819cellular_componentspindle
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005876cellular_componentspindle microtubule
D0005886cellular_componentplasma membrane
D0007186biological_processG protein-coupled receptor signaling pathway
D0008076cellular_componentvoltage-gated potassium channel complex
D0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
D0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
D0010856molecular_functionadenylate cyclase activator activity
D0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D0016020cellular_componentmembrane
D0016240biological_processautophagosome membrane docking
D0019855molecular_functioncalcium channel inhibitor activity
D0019901molecular_functionprotein kinase binding
D0021762biological_processsubstantia nigra development
D0030017cellular_componentsarcomere
D0031432molecular_functiontitin binding
D0031514cellular_componentmotile cilium
D0031954biological_processpositive regulation of protein autophosphorylation
D0031982cellular_componentvesicle
D0032465biological_processregulation of cytokinesis
D0032516biological_processobsolete positive regulation of phosphoprotein phosphatase activity
D0032991cellular_componentprotein-containing complex
D0034704cellular_componentcalcium channel complex
D0035307biological_processobsolete positive regulation of protein dephosphorylation
D0035458biological_processcellular response to interferon-beta
D0043209cellular_componentmyelin sheath
D0043539molecular_functionprotein serine/threonine kinase activator activity
D0044305cellular_componentcalyx of Held
D0044325molecular_functiontransmembrane transporter binding
D0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
D0046872molecular_functionmetal ion binding
D0048306molecular_functioncalcium-dependent protein binding
D0050848biological_processregulation of calcium-mediated signaling
D0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
D0051592biological_processresponse to calcium ion
D0055117biological_processregulation of cardiac muscle contraction
D0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
D0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
D0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
D0071346biological_processcellular response to type II interferon
D0071902biological_processpositive regulation of protein serine/threonine kinase activity
D0072542molecular_functionprotein phosphatase activator activity
D0097225cellular_componentsperm midpiece
D0098901biological_processregulation of cardiac muscle cell action potential
D0099523cellular_componentpresynaptic cytosol
D0140056biological_processorganelle localization by membrane tethering
D0140238biological_processpresynaptic endocytosis
D1901020biological_processnegative regulation of calcium ion transmembrane transporter activity
D1901842biological_processnegative regulation of high voltage-gated calcium channel activity
D1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
D1902494cellular_componentcatalytic complex
D1905913biological_processnegative regulation of calcium ion export across plasma membrane
D1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
E0000086biological_processG2/M transition of mitotic cell cycle
E0000922cellular_componentspindle pole
E0002027biological_processregulation of heart rate
E0005509molecular_functioncalcium ion binding
E0005513biological_processdetection of calcium ion
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005813cellular_componentcentrosome
E0005819cellular_componentspindle
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0005876cellular_componentspindle microtubule
E0005886cellular_componentplasma membrane
E0007186biological_processG protein-coupled receptor signaling pathway
E0008076cellular_componentvoltage-gated potassium channel complex
E0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
E0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
E0010856molecular_functionadenylate cyclase activator activity
E0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E0016020cellular_componentmembrane
E0016240biological_processautophagosome membrane docking
E0019855molecular_functioncalcium channel inhibitor activity
E0019901molecular_functionprotein kinase binding
E0021762biological_processsubstantia nigra development
E0030017cellular_componentsarcomere
E0031432molecular_functiontitin binding
E0031514cellular_componentmotile cilium
E0031954biological_processpositive regulation of protein autophosphorylation
E0031982cellular_componentvesicle
E0032465biological_processregulation of cytokinesis
E0032516biological_processobsolete positive regulation of phosphoprotein phosphatase activity
E0032991cellular_componentprotein-containing complex
E0034704cellular_componentcalcium channel complex
E0035307biological_processobsolete positive regulation of protein dephosphorylation
E0035458biological_processcellular response to interferon-beta
E0043209cellular_componentmyelin sheath
E0043539molecular_functionprotein serine/threonine kinase activator activity
E0044305cellular_componentcalyx of Held
E0044325molecular_functiontransmembrane transporter binding
E0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
E0046872molecular_functionmetal ion binding
E0048306molecular_functioncalcium-dependent protein binding
E0050848biological_processregulation of calcium-mediated signaling
E0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
E0051592biological_processresponse to calcium ion
E0055117biological_processregulation of cardiac muscle contraction
E0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
E0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
E0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
E0071346biological_processcellular response to type II interferon
E0071902biological_processpositive regulation of protein serine/threonine kinase activity
E0072542molecular_functionprotein phosphatase activator activity
E0097225cellular_componentsperm midpiece
E0098901biological_processregulation of cardiac muscle cell action potential
E0099523cellular_componentpresynaptic cytosol
E0140056biological_processorganelle localization by membrane tethering
E0140238biological_processpresynaptic endocytosis
E1901020biological_processnegative regulation of calcium ion transmembrane transporter activity
E1901842biological_processnegative regulation of high voltage-gated calcium channel activity
E1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
E1902494cellular_componentcatalytic complex
E1905913biological_processnegative regulation of calcium ion export across plasma membrane
E1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
F0005261molecular_functionmonoatomic cation channel activity
F0005886cellular_componentplasma membrane
G0005261molecular_functionmonoatomic cation channel activity
G0005886cellular_componentplasma membrane
H0005261molecular_functionmonoatomic cation channel activity
H0005886cellular_componentplasma membrane
I0005261molecular_functionmonoatomic cation channel activity
I0005886cellular_componentplasma membrane
J0005261molecular_functionmonoatomic cation channel activity
J0005886cellular_componentplasma membrane
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue MG A 201
ChainResidue
AASP21
AASP23
AASP25
ATHR27
AHOH308

site_idAC2
Number of Residues5
Detailsbinding site for residue MG A 202
ChainResidue
AHOH304
AASP57
ATHR63
AGLU68
AHOH301

site_idAC3
Number of Residues5
Detailsbinding site for residue MG A 203
ChainResidue
AASP94
AASP96
AASN98
ATYR100
AHOH306

site_idAC4
Number of Residues6
Detailsbinding site for residue MG A 204
ChainResidue
AASP130
AASP132
AASP134
AGLN136
AHOH302
AHOH305

site_idAC5
Number of Residues2
Detailsbinding site for residue SO4 A 205
ChainResidue
AHIS108
AASN112

site_idAC6
Number of Residues3
Detailsbinding site for residue SO4 F 2101
ChainResidue
AARG127
FARG1919
FHIS1923

site_idAC7
Number of Residues5
Detailsbinding site for residue MG B 201
ChainResidue
BASP21
BASP23
BASP25
BTHR27
BHOH303

site_idAC8
Number of Residues4
Detailsbinding site for residue MG B 202
ChainResidue
BASP94
BASP96
BASN98
BTYR100

site_idAC9
Number of Residues5
Detailsbinding site for residue MG B 203
ChainResidue
BASP130
BASP132
BASP134
BGLN136
BHOH302

site_idAD1
Number of Residues2
Detailsbinding site for residue PO4 B 204
ChainResidue
BHIS108
BASN112

site_idAD2
Number of Residues2
Detailsbinding site for residue SO4 G 2101
ChainResidue
GARG1826
GALA1828

site_idAD3
Number of Residues5
Detailsbinding site for residue MG C 201
ChainResidue
CASP21
CASP23
CASP25
CTHR27
CHOH304

site_idAD4
Number of Residues6
Detailsbinding site for residue MG C 202
ChainResidue
CTHR63
CGLU68
CHOH301
CHOH302
CHOH303
CHOH305

site_idAD5
Number of Residues4
Detailsbinding site for residue MG C 203
ChainResidue
CASP94
CASP96
CASN98
CTYR100

site_idAD6
Number of Residues5
Detailsbinding site for residue MG C 204
ChainResidue
CASP130
CASP132
CASP134
CGLN136
CHOH306

site_idAD7
Number of Residues2
Detailsbinding site for residue PO4 C 205
ChainResidue
CHIS108
CASN112

site_idAD8
Number of Residues1
Detailsbinding site for residue MG C 206
ChainResidue
CASP65

site_idAD9
Number of Residues3
Detailsbinding site for residue SO4 H 2101
ChainResidue
CARG127
HARG1919
HHIS1923

site_idAE1
Number of Residues5
Detailsbinding site for residue MG D 201
ChainResidue
DASP21
DASP23
DASP25
DTHR27
DHOH1103

site_idAE2
Number of Residues5
Detailsbinding site for residue MG D 202
ChainResidue
DTHR63
DHOH1101
DHOH1104
DHOH1105
DHOH1106

site_idAE3
Number of Residues5
Detailsbinding site for residue MG D 203
ChainResidue
DASP94
DASP96
DASN98
DTYR100
DHOH1108

site_idAE4
Number of Residues5
Detailsbinding site for residue MG D 204
ChainResidue
DASP130
DASP132
DASP134
DGLN136
DHOH1102

site_idAE5
Number of Residues5
Detailsbinding site for residue MG E 201
ChainResidue
EASP94
EASP96
EASN98
ETYR100
EHOH304

site_idAE6
Number of Residues6
Detailsbinding site for residue MG E 202
ChainResidue
EVAL137
EHOH301
EASP130
EASP132
EASP134
EGLN136

site_idAE7
Number of Residues2
Detailsbinding site for residue SO4 J 2101
ChainResidue
JARG1919
JHIS1923

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL
ChainResidueDetails
AASP21-LEU33
AASP57-PHE69
AASP94-LEU106
AASP130-PHE142

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues50
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03
ChainResidueDetails
AASP21
AGLU68
BASP21
BASP23
BASP25
BTHR27
BGLU32
BASP57
BASP59
BASN61
BTHR63
AASP23
BGLU68
CASP21
CASP23
CASP25
CTHR27
CGLU32
CASP57
CASP59
CASN61
CTHR63
AASP25
CGLU68
DASP21
DASP23
DASP25
DTHR27
DGLU32
DASP57
DASP59
DASN61
DTHR63
ATHR27
DGLU68
EASP21
EASP23
EASP25
ETHR27
EGLU32
EASP57
EASP59
EASN61
ETHR63
AGLU32
EGLU68
AASP57
AASP59
AASN61
ATHR63

site_idSWS_FT_FI2
Number of Residues25
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0000269|PubMed:29724949, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03, ECO:0007744|PDB:6CNN, ECO:0007744|PDB:6CNO
ChainResidueDetails
AASP94
BGLU105
CASP94
CASP96
CASN98
CTYR100
CGLU105
DASP94
DASP96
DASN98
DTYR100
AASP96
DGLU105
EASP94
EASP96
EASN98
ETYR100
EGLU105
AASN98
ATYR100
AGLU105
BASP94
BASP96
BASN98
BTYR100

site_idSWS_FT_FI3
Number of Residues25
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03
ChainResidueDetails
AASP130
BGLU141
CASP130
CASP132
CASP134
CGLN136
CGLU141
DASP130
DASP132
DASP134
DGLN136
AASP132
DGLU141
EASP130
EASP132
EASP134
EGLN136
EGLU141
AASP134
AGLN136
AGLU141
BASP130
BASP132
BASP134
BGLN136

site_idSWS_FT_FI4
Number of Residues5
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:7093203, ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712
ChainResidueDetails
AALA2
BALA2
CALA2
DALA2
EALA2

site_idSWS_FT_FI5
Number of Residues5
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS22
BLYS22
CLYS22
DLYS22
ELYS22

site_idSWS_FT_FI6
Number of Residues5
DetailsMOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250|UniProtKB:P0DP29
ChainResidueDetails
ATHR45
BTHR45
CTHR45
DTHR45
ETHR45

site_idSWS_FT_FI7
Number of Residues5
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER82
BSER82
CSER82
DSER82
ESER82

site_idSWS_FT_FI8
Number of Residues5
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS95
BLYS95
CLYS95
DLYS95
ELYS95

site_idSWS_FT_FI9
Number of Residues5
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332
ChainResidueDetails
ATYR100
BTYR100
CTYR100
DTYR100
ETYR100

site_idSWS_FT_FI10
Number of Residues5
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER102
BSER102
CSER102
DSER102
ESER102

site_idSWS_FT_FI11
Number of Residues5
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ATHR111
BTHR111
CTHR111
DTHR111
ETHR111

site_idSWS_FT_FI12
Number of Residues5
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315
ChainResidueDetails
ALYS116
BLYS116
CLYS116
DLYS116
ELYS116

site_idSWS_FT_FI13
Number of Residues5
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332
ChainResidueDetails
ATYR139
BTYR139
CTYR139
DTYR139
ETYR139

site_idSWS_FT_FI14
Number of Residues10
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157
ChainResidueDetails
ALYS22
BLYS22
CLYS22
DLYS22
ELYS22

226707

PDB entries from 2024-10-30

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