4OVN

Voltage-gated Sodium Channel 1.5 (Nav1.5) C-terminal domain in complex with Calmodulin poised for activation

Summary for 4OVN

Entry DOI	10.2210/pdb4ovn/pdb
Descriptor	Calmodulin, Sodium channel protein type 5 subunit alpha, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	scn5a, voltage gated sodium channel, calmodulin, metal binding protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	10
Total formula weight	180930.14
Authors	Gabelli, S.B.,Bianchet, M.A.,Boto, A.,Jakoncic, J.,Tomaselli, G.F.,Amzel, L.M. (deposition date: 2013-12-10, release date: 2014-12-03, Last modification date: 2023-12-27)
Primary citation	Gabelli, S.B.,Boto, A.,Kuhns, V.H.,Bianchet, M.A.,Farinelli, F.,Aripirala, S.,Yoder, J.,Jakoncic, J.,Tomaselli, G.F.,Amzel, L.M. Regulation of the NaV1.5 cytoplasmic domain by calmodulin. Nat Commun, 5:5126-, 2014 Cited by PubMed: 25370050 DOI: 10.1038/ncomms6126 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation