4OGU
The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
4OGU の概要
エントリーDOI | 10.2210/pdb4ogu/pdb |
関連するPDBエントリー | 1ZW5 4N9U 4NG6 4NUA |
分子名称 | Farnesyl pyrophosphate synthase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ... (5 entities in total) |
機能のキーワード | all alpha-helical, prenyltransferase, transferase, isoprene biosynthesis, lipid biosynthesis, steroid biosynthesis, isoprenoid pathway, cholesterol synthesis |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Cytoplasm: P14324 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 43652.99 |
構造登録者 | Tsoumpra, M.K.,Barnett, B.L.,Muniz, J.R.C.,Walter, R.L.,Ebetino, F.H.,von Delft, F.,Russell, R.G.G.,Oppermann, U.,Dunford, J.E. (登録日: 2014-01-16, 公開日: 2015-01-21, 最終更新日: 2023-09-20) |
主引用文献 | Tsoumpra, M.K.,Barnett, B.L.,Muniz, J.R.C.,Walter, R.L.,Ebetino, F.H.,von Delft, F.,Russell, R.G.G.,Oppermann, U.,Dunford, J.E. The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates To be Published, |
実験手法 | X-RAY DIFFRACTION (2.1 Å) |
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