4O2B
Tubulin-Colchicine complex
Summary for 4O2B
Entry DOI | 10.2210/pdb4o2b/pdb |
Related | 4O2A |
Descriptor | Tubulin alpha-1B chain, N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (15 entities in total) |
Functional Keywords | alpha-tubulin, beta-tubulin, ligase, gtpase, microtubule, stathmin, colchicine, cell cycle, tubulin fold, cytoskeleton, cell cycle-inhibitor complex, cell cycle/inhibitor |
Biological source | Rattus norvegicus (rat) More |
Cellular location | Cytoplasm, cytoskeleton: P81947 Cytoplasm, cytoskeleton (By similarity): Q6B856 Golgi apparatus: P63043 |
Total number of polymer chains | 6 |
Total formula weight | 266921.88 |
Authors | Prota, A.E.,Franck, D.,Bachmann, F.,Bargsten, K.,Buey, R.M.,Pohlmann, J.,Reinelt, S.,Lane, H.,Steinmetz, M.O. (deposition date: 2013-12-17, release date: 2014-03-05, Last modification date: 2023-09-20) |
Primary citation | Prota, A.E.,Danel, F.,Bachmann, F.,Bargsten, K.,Buey, R.M.,Pohlmann, J.,Reinelt, S.,Lane, H.,Steinmetz, M.O. The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization. J.Mol.Biol., 426:1848-1860, 2014 Cited by PubMed: 24530796DOI: 10.1016/j.jmb.2014.02.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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