Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4NKA

Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with pyrazolaminopyrimidine 2

Summary for 4NKA
Entry DOI10.2210/pdb4nka/pdb
Related4F63 4F64 4F65 4NK9 4NKS
DescriptorFibroblast growth factor receptor 1, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordskinase, atp binding, phosphorylation, trans-membrane, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type I membrane protein: P11362
Total number of polymer chains2
Total formula weight71616.03
Authors
Norman, R.A.,Klein, T. (deposition date: 2013-11-12, release date: 2013-12-18, Last modification date: 2024-02-28)
Primary citationKlein, T.,Tucker, J.,Holdgate, G.A.,Norman, R.A.,Breeze, A.L.
FGFR1 Kinase Inhibitors: Close Regioisomers Adopt Divergent Binding Modes and Display Distinct Biophysical Signatures.
ACS Med Chem Lett, 5:166-171, 2014
Cited by
PubMed: 24900792
DOI: 10.1021/ml4004205
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.19 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon