4F65

Crystal structure of Human Fibroblast Growth Factor Receptor 1 Kinase domain in complex with compound 8

Summary for 4F65

• Entry DOI: 10.2210/pdb4f65/pdb
• Related: 4F63 4F64
• Descriptor: Fibroblast growth factor receptor 1, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: kinase, atp binding, phosphorylation, trans-membrane, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Single-pass type I membrane protein: P11362
• Total number of polymer chains: 2
• Total formula weight: 72184.26

Authors

Norman, R.A.,Breed, J.,Ogg, D. (deposition date: 2012-05-14, release date: 2012-06-06, Last modification date: 2024-02-28)

• Primary citation: Norman, R.A.,Schott, A.K.,Andrews, D.M.,Breed, J.,Foote, K.M.,Garner, A.P.,Ogg, D.,Orme, J.P.,Pink, J.H.,Roberts, K.,Rudge, D.A.,Thomas, A.P.,Leach, A.G.; Protein-Ligand Crystal Structures Can Guide the Design of Selective Inhibitors of the FGFR Tyrosine Kinase.; J.Med.Chem., 55:5003-5012, 2012; PubMed: 22612866; DOI: 10.1021/jm3004043

Experimental method

X-RAY DIFFRACTION (2.26 Å)