4NKS
Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with pyrazolaminopyrimidine 3
Summary for 4NKS
| Entry DOI | 10.2210/pdb4nks/pdb |
| Related | 4F63 4F64 4F65 4NK9 4NKA |
| Descriptor | Fibroblast growth factor receptor 1, N~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]-N~4~-[5-(2-phenylethyl)-1H-pyrazol-3-yl]pyrimidine-2,4-diamine (3 entities in total) |
| Functional Keywords | kinase, atp binding, phosphorylation, trans-membrane, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cell membrane; Single-pass type I membrane protein: P11362 |
| Total number of polymer chains | 2 |
| Total formula weight | 71021.53 |
| Authors | Norman, R.A.,Klein, T. (deposition date: 2013-11-13, release date: 2013-12-18, Last modification date: 2024-02-28) |
| Primary citation | Klein, T.,Tucker, J.,Holdgate, G.A.,Norman, R.A.,Breeze, A.L. FGFR1 Kinase Inhibitors: Close Regioisomers Adopt Divergent Binding Modes and Display Distinct Biophysical Signatures. ACS Med Chem Lett, 5:166-171, 2014 Cited by PubMed: 24900792DOI: 10.1021/ml4004205 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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