4NK9

Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with pyrazolaminopyrimidine 1

Summary for 4NK9

Entry DOI	10.2210/pdb4nk9/pdb
Related	4F63 4F64 4F65 4NKA 4NKS
Descriptor	FIBROBLAST GROWTH FACTOR RECEPTOR 1, 1,2-ETHANEDIOL, SULFATE ION, ... (5 entities in total)
Functional Keywords	kinase, atp binding, phosphorylation, trans-membrane, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cell membrane; Single-pass type I membrane protein: P11362
Total number of polymer chains	2
Total formula weight	71678.10
Authors	Norman, R.A.,Klein, T. (deposition date: 2013-11-12, release date: 2013-12-18, Last modification date: 2024-02-28)
Primary citation	Klein, T.,Tucker, J.,Holdgate, G.A.,Norman, R.A.,Breeze, A.L. FGFR1 Kinase Inhibitors: Close Regioisomers Adopt Divergent Binding Modes and Display Distinct Biophysical Signatures. ACS Med Chem Lett, 5:166-171, 2014 Cited by PubMed: 24900792 DOI: 10.1021/ml4004205 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.57 Å)

Structure validation