4MVD

Crystal Structure of a Mammalian Cytidylyltransferase

4MVD の概要

• エントリーDOI: 10.2210/pdb4mvd/pdb
• 関連するPDBエントリー: 3HL4 4MVC
• 分子名称: Choline-phosphate cytidylyltransferase A, [2-CYTIDYLATE-O'-PHOSPHONYLOXYL]-ETHYL-TRIMETHYL-AMMONIUM (2 entities in total)
• 機能のキーワード: rossmann fold, amphipathic helix, four-helix bundle, lipid membrane binding, cytidine 5'-diphosphocholine synthesis, phosphatidylcholine homeostasis, lipid membrane surface, endoplasmic reticulum, nucleus, transferase
• 由来する生物種: Rattus norvegicus (rat)
• 細胞内の位置: Cytoplasm, cytosol: P19836
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 308395.00

構造登録者

Lee, J.,Cornell, R.B. (登録日: 2013-09-23, 公開日: 2013-12-11, 最終更新日: 2024-02-28)

• 主引用文献: Lee, J.,Taneva, S.G.,Holland, B.W.,Tieleman, D.P.,Cornell, R.B.; Structural Basis for Autoinhibition of CTP:Phosphocholine Cytidylyltransferase (CCT), the Regulatory Enzyme in Phosphatidylcholine Synthesis, by Its Membrane-binding Amphipathic Helix.; J.Biol.Chem., 289:1742-1755, 2014; PubMed: 24275660; DOI: 10.1074/jbc.M113.526970

実験手法

X-RAY DIFFRACTION (8 Å)