4MVD

Crystal Structure of a Mammalian Cytidylyltransferase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004105	molecular_function	choline-phosphate cytidylyltransferase activity
A	0006657	biological_process	CDP-choline pathway
A	0009058	biological_process	biosynthetic process
B	0003824	molecular_function	catalytic activity
B	0004105	molecular_function	choline-phosphate cytidylyltransferase activity
B	0006657	biological_process	CDP-choline pathway
B	0009058	biological_process	biosynthetic process
C	0003824	molecular_function	catalytic activity
C	0004105	molecular_function	choline-phosphate cytidylyltransferase activity
C	0006657	biological_process	CDP-choline pathway
C	0009058	biological_process	biosynthetic process
D	0003824	molecular_function	catalytic activity
D	0004105	molecular_function	choline-phosphate cytidylyltransferase activity
D	0006657	biological_process	CDP-choline pathway
D	0009058	biological_process	biosynthetic process
E	0003824	molecular_function	catalytic activity
E	0004105	molecular_function	choline-phosphate cytidylyltransferase activity
E	0006657	biological_process	CDP-choline pathway
E	0009058	biological_process	biosynthetic process
F	0003824	molecular_function	catalytic activity
F	0004105	molecular_function	choline-phosphate cytidylyltransferase activity
F	0006657	biological_process	CDP-choline pathway
F	0009058	biological_process	biosynthetic process
G	0003824	molecular_function	catalytic activity
G	0004105	molecular_function	choline-phosphate cytidylyltransferase activity
G	0006657	biological_process	CDP-choline pathway
G	0009058	biological_process	biosynthetic process
H	0003824	molecular_function	catalytic activity
H	0004105	molecular_function	choline-phosphate cytidylyltransferase activity
H	0006657	biological_process	CDP-choline pathway
H	0009058	biological_process	biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CDC B 401

Chain	Residue
B	ASP82
B	ARG196
B	THR197
B	ILE200
B	GLY83
B	ILE84
B	PHE85
B	ALA95
B	PRO150
B	TRP151
B	ASP169
B	GLN195

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CDC A 401

Chain	Residue
A	ASP82
A	GLY83
A	ILE84
A	PHE85
A	GLY91
A	ALA95
A	TRP151
A	ASP169
A	GLN195
A	ARG196
A	THR197
A	ILE200

---

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CDC D 401

Chain	Residue
D	ASP82
D	GLY83
D	ILE84
D	PHE85
D	ALA95
D	PRO150
D	TRP151
D	ASP169
D	GLN195
D	ARG196
D	THR197
D	ILE200

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CDC C 401

Chain	Residue
C	ASP82
C	GLY83
C	ILE84
C	PHE85
C	GLY91
C	ALA95
C	TRP151
C	ASP169
C	GLN195
C	ARG196
C	THR197
C	ILE200

---

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CDC F 401

Chain	Residue
F	ASP82
F	GLY83
F	ILE84
F	PHE85
F	ALA95
F	PRO150
F	TRP151
F	ASP169
F	GLN195
F	ARG196
F	THR197
F	ILE200

---

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CDC E 401

Chain	Residue
E	ASP82
E	GLY83
E	ILE84
E	PHE85
E	GLY91
E	ALA95
E	TRP151
E	ASP169
E	GLN195
E	ARG196
E	THR197
E	ILE200

---

site_id	AC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CDC H 401

Chain	Residue
H	ASP82
H	GLY83
H	ILE84
H	PHE85
H	ALA95
H	PRO150
H	TRP151
H	ASP169
H	GLN195
H	ARG196
H	THR197
H	ILE200

---

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CDC G 401

Chain	Residue
G	ASP82
G	GLY83
G	ILE84
G	PHE85
G	GLY91
G	ALA95
G	TRP151
G	ASP169
G	GLN195
G	ARG196
G	THR197
G	ILE200

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19783652","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24275660","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3HL4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MVD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19783652","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3HL4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MVD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19783652","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24275660","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3HL4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MVC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19783652","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24275660","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3HL4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P49585","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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