4MVD

Crystal Structure of a Mammalian Cytidylyltransferase

Summary for 4MVD

Entry DOI	10.2210/pdb4mvd/pdb
Related	3HL4 4MVC
Descriptor	Choline-phosphate cytidylyltransferase A, [2-CYTIDYLATE-O'-PHOSPHONYLOXYL]-ETHYL-TRIMETHYL-AMMONIUM (2 entities in total)
Functional Keywords	rossmann fold, amphipathic helix, four-helix bundle, lipid membrane binding, cytidine 5'-diphosphocholine synthesis, phosphatidylcholine homeostasis, lipid membrane surface, endoplasmic reticulum, nucleus, transferase
Biological source	Rattus norvegicus (rat)
Cellular location	Cytoplasm, cytosol: P19836
Total number of polymer chains	8
Total formula weight	308395.00
Authors	Lee, J.,Cornell, R.B. (deposition date: 2013-09-23, release date: 2013-12-11, Last modification date: 2024-02-28)
Primary citation	Lee, J.,Taneva, S.G.,Holland, B.W.,Tieleman, D.P.,Cornell, R.B. Structural Basis for Autoinhibition of CTP:Phosphocholine Cytidylyltransferase (CCT), the Regulatory Enzyme in Phosphatidylcholine Synthesis, by Its Membrane-binding Amphipathic Helix. J.Biol.Chem., 289:1742-1755, 2014 Cited by PubMed: 24275660 DOI: 10.1074/jbc.M113.526970 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (8 Å)

Structure validation