4MVC
Crystal Structure of a Mammalian Cytidylyltransferase
Summary for 4MVC
Entry DOI | 10.2210/pdb4mvc/pdb |
Related | 3HL4 4MVD |
Descriptor | Choline-phosphate cytidylyltransferase A, [2-CYTIDYLATE-O'-PHOSPHONYLOXYL]-ETHYL-TRIMETHYL-AMMONIUM (3 entities in total) |
Functional Keywords | rossmann fold, amphipathic helix, lipid membrane binding, cytidine 5 -diphosphocholine synthesis, phosphatidylcholine homeostasis, lipid membrane surface, endoplasmic reticulum, nucleus, transferase |
Biological source | Rattus norvegicus (brown rat,rat,rats) More |
Cellular location | Cytoplasm, cytosol : P19836 |
Total number of polymer chains | 2 |
Total formula weight | 69191.53 |
Authors | Lee, J.,Cornell, R.B. (deposition date: 2013-09-23, release date: 2013-12-11, Last modification date: 2023-09-20) |
Primary citation | Lee, J.,Taneva, S.G.,Holland, B.W.,Tieleman, D.P.,Cornell, R.B. Structural Basis for Autoinhibition of CTP:Phosphocholine Cytidylyltransferase (CCT), the Regulatory Enzyme in Phosphatidylcholine Synthesis, by Its Membrane-binding Amphipathic Helix. J.Biol.Chem., 289:1742-1755, 2014 Cited by PubMed: 24275660DOI: 10.1074/jbc.M113.526970 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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