4MVC
Crystal Structure of a Mammalian Cytidylyltransferase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004105 | molecular_function | choline-phosphate cytidylyltransferase activity |
| A | 0006657 | biological_process | CDP-choline pathway |
| A | 0009058 | biological_process | biosynthetic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004105 | molecular_function | choline-phosphate cytidylyltransferase activity |
| B | 0006657 | biological_process | CDP-choline pathway |
| B | 0009058 | biological_process | biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE CDC A 401 |
| Chain | Residue |
| A | ASP82 |
| A | HIS168 |
| A | ASP169 |
| A | TYR173 |
| A | TYR182 |
| A | GLN195 |
| A | ARG196 |
| A | THR197 |
| A | ILE200 |
| A | HOH504 |
| A | GLY83 |
| A | ILE84 |
| A | PHE85 |
| A | HIS89 |
| A | GLY91 |
| A | ALA95 |
| A | LYS122 |
| A | TRP151 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE CDC B 401 |
| Chain | Residue |
| B | ASP82 |
| B | GLY83 |
| B | ILE84 |
| B | PHE85 |
| B | HIS89 |
| B | GLY91 |
| B | HIS92 |
| B | ALA95 |
| B | LYS122 |
| B | PRO150 |
| B | TRP151 |
| B | HIS168 |
| B | ASP169 |
| B | TYR173 |
| B | TYR182 |
| B | GLN195 |
| B | ARG196 |
| B | THR197 |
| B | ILE200 |
| B | HOH502 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:19783652, ECO:0000305|PubMed:24275660, ECO:0007744|PDB:3HL4, ECO:0007744|PDB:4MVC, ECO:0007744|PDB:4MVD |
| Chain | Residue | Details |
| A | ILE84 | |
| B | ARG196 | |
| B | THR197 | |
| B | ILE200 | |
| A | PHE85 | |
| A | GLN195 | |
| A | ARG196 | |
| A | THR197 | |
| A | ILE200 | |
| B | ILE84 | |
| B | PHE85 | |
| B | GLN195 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:19783652, ECO:0007744|PDB:3HL4, ECO:0007744|PDB:4MVC, ECO:0007744|PDB:4MVD |
| Chain | Residue | Details |
| A | HIS92 | |
| B | HIS92 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:19783652, ECO:0000305|PubMed:24275660, ECO:0007744|PDB:3HL4, ECO:0007744|PDB:4MVC |
| Chain | Residue | Details |
| A | LYS122 | |
| A | HIS168 | |
| A | ASP169 | |
| A | TYR173 | |
| B | LYS122 | |
| B | HIS168 | |
| B | ASP169 | |
| B | TYR173 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:19783652, ECO:0000305|PubMed:24275660, ECO:0007744|PDB:3HL4 |
| Chain | Residue | Details |
| A | TRP151 | |
| B | TRP151 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:P49585 |
| Chain | Residue | Details |
| A | MET1 | |
| B | MET1 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P49585 |
| Chain | Residue | Details |
| A | LYS8 | |
| B | LYS8 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P49585 |
| Chain | Residue | Details |
| A | SER265 | |
| B | SER265 |
