3HL4

Crystal structure of a mammalian CTP:phosphocholine cytidylyltransferase with CDP-choline

Summary for 3HL4

Entry DOI	10.2210/pdb3hl4/pdb
Descriptor	Choline-phosphate cytidylyltransferase A, [2-CYTIDYLATE-O'-PHOSPHONYLOXYL]-ETHYL-TRIMETHYL-AMMONIUM, GLYCEROL, ... (5 entities in total)
Functional Keywords	cytidylyltransferase, rossmann fold, phospholipid synthesis, phosphatidylcholine, phosphocholine, ctp, cdp-choline, amphitropic protein, lipid metabolism, nucleotidyltransferase, phosphoprotein, transferase
Biological source	Rattus norvegicus (rat)
Cellular location	Cytoplasm, cytosol: P19836
Total number of polymer chains	2
Total formula weight	54975.05
Authors	Lee, J.,Paetzel, M.,Cornell, R.B. (deposition date: 2009-05-26, release date: 2009-09-22, Last modification date: 2024-02-21)
Primary citation	Lee, J.,Johnson, J.E.,Ding, Z.,Paetzel, M.,Cornell, R.B. Crystal Structure of a mammalian CTP: Phosphocholine cytidylyltransferase catalytic domain reveals novel active site residues within a highly conserved nucleotidyl-transferase fold J.Biol.Chem., 284:33535-33548, 2009 Cited by PubMed: 19783652 DOI: 10.1074/jbc.M109.053363 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation