3HL4

Crystal structure of a mammalian CTP:phosphocholine cytidylyltransferase with CDP-choline

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004105	molecular_function	choline-phosphate cytidylyltransferase activity
A	0006657	biological_process	CDP-choline pathway
A	0009058	biological_process	biosynthetic process
B	0003824	molecular_function	catalytic activity
B	0004105	molecular_function	choline-phosphate cytidylyltransferase activity
B	0006657	biological_process	CDP-choline pathway
B	0009058	biological_process	biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	BINDING SITE FOR RESIDUE CDC A 237

Chain	Residue
A	ASP82
A	LYS122
A	PRO150
A	TRP151
A	HIS168
A	ASP169
A	TYR173
A	TYR182
A	GLN195
A	ARG196
A	THR197
A	GLY83
A	ILE200
A	HOH401
A	HOH403
A	HOH404
A	HOH405
A	HOH406
A	ILE84
A	PHE85
A	HIS89
A	GLY91
A	HIS92
A	ALA95
A	CYS113

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 238

Chain	Residue
A	ASP170
A	LYS186
A	PRO193
A	HOH502
A	HOH515
A	HOH517
B	ALA159
B	HOH447

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 239

Chain	Residue
A	GLU198
A	GLY199
A	HOH416
B	GLU131

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT A 240

Chain	Residue
A	ARG196
A	HOH415
B	VAL60

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site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 241

Chain	Residue
A	ARG42
A	GLN43
A	GLU187
B	ASN101

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT A 242

Chain	Residue
A	GLU198
A	HOH499

---

site_id	AC7
Number of Residues	25
Details	BINDING SITE FOR RESIDUE CDC B 237

Chain	Residue
B	ASP82
B	GLY83
B	ILE84
B	PHE85
B	HIS89
B	GLY91
B	HIS92
B	ALA95
B	CYS113
B	LYS122
B	PRO150
B	TRP151
B	HIS168
B	ASP169
B	TYR173
B	TYR182
B	GLN195
B	ARG196
B	THR197
B	ILE200
B	HOH401
B	HOH403
B	HOH404
B	HOH405
B	HOH406

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT B 238

Chain	Residue
B	SER178
B	ASP179

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT B 239

Chain	Residue
B	PHE47
B	SER48
B	ASP49
B	VAL146
B	ARG147

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT B 240

Chain	Residue
B	ASN128
B	ASN130

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19783652","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24275660","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3HL4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MVD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19783652","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3HL4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MVD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19783652","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24275660","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3HL4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MVC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19783652","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24275660","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3HL4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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