4MVC

Crystal Structure of a Mammalian Cytidylyltransferase

Summary for 4MVC

Entry DOI	10.2210/pdb4mvc/pdb
Related	3HL4 4MVD
Descriptor	Choline-phosphate cytidylyltransferase A, [2-CYTIDYLATE-O'-PHOSPHONYLOXYL]-ETHYL-TRIMETHYL-AMMONIUM (3 entities in total)
Functional Keywords	rossmann fold, amphipathic helix, lipid membrane binding, cytidine 5 -diphosphocholine synthesis, phosphatidylcholine homeostasis, lipid membrane surface, endoplasmic reticulum, nucleus, transferase
Biological source	Rattus norvegicus (brown rat,rat,rats) More
Cellular location	Cytoplasm, cytosol : P19836
Total number of polymer chains	2
Total formula weight	69191.53
Authors	Lee, J.,Cornell, R.B. (deposition date: 2013-09-23, release date: 2013-12-11, Last modification date: 2023-09-20)
Primary citation	Lee, J.,Taneva, S.G.,Holland, B.W.,Tieleman, D.P.,Cornell, R.B. Structural Basis for Autoinhibition of CTP:Phosphocholine Cytidylyltransferase (CCT), the Regulatory Enzyme in Phosphatidylcholine Synthesis, by Its Membrane-binding Amphipathic Helix. J.Biol.Chem., 289:1742-1755, 2014 Cited by PubMed: 24275660 DOI: 10.1074/jbc.M113.526970 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation