4MNX
Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK811
Summary for 4MNX
Entry DOI | 10.2210/pdb4mnx/pdb |
Related | 2NWN 3QN7 4GLY 4JK5 4JK6 4MNV 4MNW 4MNY |
Related PRD ID | PRD_001167 |
Descriptor | Urokinase-type plasminogen activator chain B, bicyclic peptide UK811, SULFATE ION, ... (6 entities in total) |
Functional Keywords | competitive inhibitor, bicyclic peptide, inhibitor, protease, 1, 1', 1''-(1, 3, 5-triazinane-1, 5-triyl)triprop-2-en-1-one (tata) cyclization, extracellular, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P00749 |
Total number of polymer chains | 2 |
Total formula weight | 29696.77 |
Authors | Chen, S.,Pojer, F.,Heinis, C. (deposition date: 2013-09-11, release date: 2014-02-05, Last modification date: 2017-11-15) |
Primary citation | Chen, S.,Bertoldo, D.,Angelini, A.,Pojer, F.,Heinis, C. Peptide ligands stabilized by small molecules. Angew.Chem.Int.Ed.Engl., 53:1602-1606, 2014 Cited by PubMed: 24453110DOI: 10.1002/anie.201309459 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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