4MNX
Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK811
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Urokinase-type plasminogen activator chain B | polymer | 245 | 27586.4 | 1 | UniProt (P00749) Pfam (PF00089) In PDB | Homo sapiens (human) | U-plasminogen activator, uPA |
| 2 | B | bicyclic peptide UK811 | polymer | 14 | 1570.8 | 1 | BIRD (PRD_001167) | ||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | B | 1,1',1''-(1,3,5-triazinane-1,3,5-triyl)tripropan-1-one | non-polymer | 255.3 | 1 | BIRD (PRD_001167) Chemie (29N) | |||
| 6 | water | water | 18.0 | 128 | Chemie (HOH) |
Sequence modifications
A: 16 - 242 (UniProt: P00749)
| PDB | External Database | Details |
|---|---|---|
| Ala 122 | Cys 299 | ENGINEERED MUTATION |
| Gln 145 | Asn 322 | ENGINEERED MUTATION |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29157.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 539.5 | |
| All* | Total formula weight | 29696.8 |
