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4MNX

Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK811

Functional Information from GO Data
ChainGOidnamespacecontents
A0004252molecular_functionserine-type endopeptidase activity
A0006508biological_processproteolysis
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 301
ChainResidue
ALYS61
AHIS100
ATHR177
ALYS179
AMET180
AHOH432
AHOH461

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 302
ChainResidue
AHIS165
AARG166
AARG206
APHE132
ASER164

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL A 303
ChainResidue
AARG35
AHIS37
AARG37
AHOH509
AHOH513

site_idAC4
Number of Residues43
DetailsBINDING SITE FOR BICYCLIC PEPTIDE UK811
ChainResidue
AGLY18
AGLY19
AGLU20
APHE21
AASN26
AARG35
AVAL41
ACYS42
AHIS57
ACYS58
AASP60
ATYR60
ATYR64
ATHR97
ALEU97
AGLU144
AGLN145
AASP148
ALYS156
AASP189
ASER190
ACYS191
AGLN192
AGLY193
ASER195
ASER214
ATRP215
AGLY216
AGLY218
AGLY226
AHOH420
AHOH430
AHOH434
AHOH435
AHOH466
BHOH201
BHOH202
BHOH203
BHOH204
BHOH205
BHOH206
BHOH208
BHOH209

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. ISATHC
ChainResidueDetails
AILE53-CYS58

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV
ChainResidueDetails
AASP189-VAL200

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Charge relay system
ChainResidueDetails
AHIS57
AASP102
ASER195

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:9151681
ChainResidueDetails
ASER146

site_idSWS_FT_FI3
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine
ChainResidueDetails
AGLN145

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PDB entries from 2024-07-24

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