4M1S
Crystal Structure of small molecule vinylsulfonamide 13 covalently bound to K-Ras G12C
Summary for 4M1S
Entry DOI | 10.2210/pdb4m1s/pdb |
Related | 4L8G 4L9S 4L9W 4LPK 4LRW 4LUC 4LV6 4LYF 4LYH 4LYJ 4M1O 4M1T 4M1W 4M1Y 4M21 4M22 |
Descriptor | K-Ras GTPase, GUANOSINE-5'-DIPHOSPHATE, N-{1-[N-(2,4-dichlorophenyl)glycyl]piperidin-4-yl}ethanesulfonamide, ... (4 entities in total) |
Functional Keywords | gtpase, gdp bound, small molecule inhibitor, covalent binder, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116 |
Total number of polymer chains | 3 |
Total formula weight | 59782.28 |
Authors | Ostrem, J.M.,Peters, U.,Sos, M.L.,Wells, J.A.,Shokat, K.M. (deposition date: 2013-08-04, release date: 2013-11-27, Last modification date: 2023-09-20) |
Primary citation | Ostrem, J.M.,Peters, U.,Sos, M.L.,Wells, J.A.,Shokat, K.M. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503:548-551, 2013 Cited by PubMed: 24256730DOI: 10.1038/nature12796 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.552 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)