4LZ1
X-ray structure of the complex between human thrombin and the TBA deletion mutant lacking thymine 12 nucleobase
Summary for 4LZ1
Entry DOI | 10.2210/pdb4lz1/pdb |
Related | 3QLP 4DIH 4DII 4LZ4 |
Related PRD ID | PRD_000020 |
Descriptor | Thrombin light chain, Thrombin heavy chain, Thrombin Binding Aptamer, ... (8 entities in total) |
Functional Keywords | protein-dna complex, blood coagulation, aptamer, inhibitor-dna complex, dna aptamer, g-quadruplex, serine protease, hydrolase, abasic furan, dna thymine nucleobase deletion, blood, hydrolase-dna complex, hydrolase-hydrolase inhibitor-dna complex, hydrolase/hydrolase inhibitor/dna |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 39232.99 |
Authors | Pica, A.,Russo Krauss, I.,Merlino, A.,Sica, F. (deposition date: 2013-07-31, release date: 2014-01-08, Last modification date: 2020-07-29) |
Primary citation | Pica, A.,Russo Krauss, I.,Merlino, A.,Nagatoishi, S.,Sugimoto, N.,Sica, F. Dissecting the contribution of thrombin exosite I in the recognition of thrombin binding aptamer. Febs J., 280:6581-6588, 2013 Cited by PubMed: 24128303DOI: 10.1111/febs.12561 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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