4LZ1

X-ray structure of the complex between human thrombin and the TBA deletion mutant lacking thymine 12 nucleobase

4LZ1 の概要

• エントリーDOI: 10.2210/pdb4lz1/pdb
• 関連するPDBエントリー: 3QLP 4DIH 4DII 4LZ4
• 関連するBIRD辞書のPRD_ID: PRD_000020
• 分子名称: Thrombin light chain, Thrombin heavy chain, Thrombin Binding Aptamer, ... (8 entities in total)
• 機能のキーワード: protein-dna complex, blood coagulation, aptamer, inhibitor-dna complex, dna aptamer, g-quadruplex, serine protease, hydrolase, abasic furan, dna thymine nucleobase deletion, blood, hydrolase-dna complex, hydrolase-hydrolase inhibitor-dna complex, hydrolase/hydrolase inhibitor/dna
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 39232.99

構造登録者

Pica, A.,Russo Krauss, I.,Merlino, A.,Sica, F. (登録日: 2013-07-31, 公開日: 2014-01-08, 最終更新日: 2020-07-29)

• 主引用文献: Pica, A.,Russo Krauss, I.,Merlino, A.,Nagatoishi, S.,Sugimoto, N.,Sica, F.; Dissecting the contribution of thrombin exosite I in the recognition of thrombin binding aptamer.; Febs J., 280:6581-6588, 2013; PubMed: 24128303; DOI: 10.1111/febs.12561

実験手法

X-RAY DIFFRACTION (1.65 Å)