4LIF

Crystal structure of the JCV large T-antigen origin binding domain

Summary for 4LIF

Entry DOI	10.2210/pdb4lif/pdb
Related	4LMD 4NBP
Descriptor	Large T antigen, SULFATE ION (3 entities in total)
Functional Keywords	origin binding domain, replication, polyomavirus, hydrolase, dna binding protein
Biological source	JC polyomavirus (JCPyV)
Cellular location	Host nucleus (By similarity): P03072
Total number of polymer chains	1
Total formula weight	15362.52
Authors	Meinke, G.,Bohm, A.,Bullock, P. (deposition date: 2013-07-02, release date: 2014-03-05, Last modification date: 2023-09-20)
Primary citation	Meinke, G.,Phelan, P.J.,Kalekar, R.,Shin, J.,Archambault, J.,Bohm, A.,Bullock, P.A. Insights into the Initiation of JC Virus DNA Replication Derived from the Crystal Structure of the T-Antigen Origin Binding Domain. Plos Pathog., 10:e1003966-e1003966, 2014 Cited by PubMed: 24586168 DOI: 10.1371/journal.ppat.1003966 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation