4LB9

X-ray study of human serum albumin complexed with etoposide

4LB9 の概要

• エントリーDOI: 10.2210/pdb4lb9/pdb
• 関連するPDBエントリー: 4L8U 4L9K 4L9Q 4LA0 4LB2
• 分子名称: SERUM ALBUMIN, MYRISTIC ACID, (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, ... (4 entities in total)
• 機能のキーワード: plasma protein, cancer, oncology drug complex, transport protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P02768
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 68073.26

構造登録者

Wang, Z.,Ho, J.X.,Ruble, J.,Rose, J.P.,Carter, D.C. (登録日: 2013-06-20, 公開日: 2013-07-24, 最終更新日: 2024-11-06)

主引用文献

Wang, Z.M.,Ho, J.X.,Ruble, J.R.,Rose, J.,Ruker, F.,Ellenburg, M.,Murphy, R.,Click, J.,Soistman, E.,Wilkerson, L.,Carter, D.C.
Structural studies of several clinically important oncology drugs in complex with human serum albumin.
Biochim.Biophys.Acta, 1830:5356-5374, 2013

PubMed Abstract: Serum albumin is a major pharmacokinetic effector of drugs. To gain further insight into albumin binding chemistry, the crystal structures of six oncology agents were determined in complex with human serum albumin at resolutions of 2.8 to 2.0Å: camptothecin, 9-amino-camptothecin, etoposide, teniposide, bicalutamide and idarubicin.

PubMed: 23838380
DOI: 10.1016/j.bbagen.2013.06.032

実験手法

X-RAY DIFFRACTION (2.7 Å)