4L4J

Crystal structure of fc-fragment of human IgG2-Sigma antibody

Summary for 4L4J

• Entry DOI: 10.2210/pdb4l4j/pdb
• Related: 4HAF 4HAG
• Descriptor: Ig gamma-2 chain C region, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: immunoglobulin fold, immune system
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P01859
• Total number of polymer chains: 2
• Total formula weight: 51930.28

Authors

Teplyakov, A.,Malia, T.,Gillilang, G. (deposition date: 2013-06-07, release date: 2013-08-28, Last modification date: 2023-09-20)

• Primary citation: Vafa, O.,Gilliland, G.L.,Brezski, R.J.,Strake, B.,Wilkinson, T.,Lacy, E.R.,Scallon, B.,Teplyakov, A.,Malia, T.J.,Strohl, W.R.; An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations.; Methods, 65:114-126, 2014; PubMed: 23872058; DOI: 10.1016/j.ymeth.2013.06.035

Experimental method

X-RAY DIFFRACTION (1.92 Å)